Endocrine Abstracts

Objectives: Reduced bone mass and compromised bone quality characterise osteoporosis. A positive relationship of the body-mass-index or the body fat mass and the bone density has been reported by several clinical studies. However, it is not clear whether this observation is attributable to higher mechanical stress or whether adipocytes secrete products that directly affect the bone structure.Methods: Isolation of human primary adipocytes to generate fat-...

Objective: Recently, we have shown that endothelial cell-conditioned medium (ECCM) stimulates aldosterone secretion and the expression of proteins, essential for steroidogenesis and adrenal development. Also, we have found that fat cells regulate adrenal steroidogenesis through the wnt-signaling pathway. In addition, β-catenin was implicated in adrenal tumorigenesis, including aldosterone-producing adenomas.Methods: We studied the influence of endot...